Prion protein glycans reduce intracerebral fibril formation and spongiosis in prion disease

Posttranslational modifications (PTMs) are common among proteins that aggregate in neurodegenerative disease, yet how PTMs impact the aggregate conformation and disease progression remains unclear. By engineering knockin mice expressing prion protein (PrP) lacking 2 N-linked glycans (Prnp(180Q/196Q)...

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Vydáno v:J Clin Invest
Hlavní autoři: Sevillano, Alejandro M., Aguilar-Calvo, Patricia, Kurt, Timothy D., Lawrence, Jessica A., Soldau, Katrin, Nam, Thu H., Schumann, Taylor, Pizzo, Donald P., Nyström, Sofie, Choudhury, Biswa, Altmeppen, Hermann, Esko, Jeffrey D., Glatzel, Markus, Nilsson, K. Peter R., Sigurdson, Christina J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7269597/
https://ncbi.nlm.nih.gov/pubmed/31985492
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI131564
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