Shortening heparan sulfate chains prolongs survival and reduces parenchymal plaques in prion disease caused by mobile, ADAM10-cleaved prions

Cofactors are essential for driving recombinant prion protein into pathogenic conformers. Polyanions promote prion aggregation in vitro, yet the cofactors that modulate prion assembly in vivo remain largely unknown. Here we report that the endogenous glycosaminoglycan, heparan sulfate (HS), impacts...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol
Main Authors: Aguilar-Calvo, Patricia, Sevillano, Alejandro M., Bapat, Jaidev, Soldau, Katrin, Sandoval, Daniel R., Altmeppen, Hermann C., Linsenmeier, Luise, Pizzo, Donald P., Geschwind, Michael, Sanchez, Henry, Appleby, Brian, Cohen, Mark, Safar, Jiri G., Edland, Steven D., Glatzel, Markus, Nilsson, K. Peter R., Esko, Jeffrey D., Sigurdson, Christina J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7036335/
https://ncbi.nlm.nih.gov/pubmed/31673874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00401-019-02085-x
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