The sheddase ADAM10 is a potent modulator of prion disease

The prion protein (PrP(C)) is highly expressed in the nervous system and critically involved in prion diseases where it misfolds into pathogenic PrP(Sc). Moreover, it has been suggested as a receptor mediating neurotoxicity in common neurodegenerative proteinopathies such as Alzheimer's disease...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Altmeppen, Hermann C, Prox, Johannes, Krasemann, Susanne, Puig, Berta, Kruszewski, Katharina, Dohler, Frank, Bernreuther, Christian, Hoxha, Ana, Linsenmeier, Luise, Sikorska, Beata, Liberski, Pawel P, Bartsch, Udo, Saftig, Paul, Glatzel, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2015
Assuntos:
Microbiology and Infectious Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4346534/
https://ncbi.nlm.nih.gov/pubmed/25654651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.04260
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