The sheddase ADAM10 is a potent modulator of prion disease

The prion protein (PrP(C)) is highly expressed in the nervous system and critically involved in prion diseases where it misfolds into pathogenic PrP(Sc). Moreover, it has been suggested as a receptor mediating neurotoxicity in common neurodegenerative proteinopathies such as Alzheimer's disease...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Altmeppen, Hermann C, Prox, Johannes, Krasemann, Susanne, Puig, Berta, Kruszewski, Katharina, Dohler, Frank, Bernreuther, Christian, Hoxha, Ana, Linsenmeier, Luise, Sikorska, Beata, Liberski, Pawel P, Bartsch, Udo, Saftig, Paul, Glatzel, Markus
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2015
Fag:
Microbiology and Infectious Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4346534/
https://ncbi.nlm.nih.gov/pubmed/25654651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.04260
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