Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo

BACKGROUND: The cellular prion protein (PrP(C)) fulfils several yet not completely understood physiological functions. Apart from these functions, it has the ability to misfold into a pathogenic scrapie form (PrP(Sc)) leading to fatal transmissible spongiform encephalopathies. Proteolytic processing...

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Hauptverfasser: Altmeppen, Hermann C, Prox, Johannes, Puig, Berta, Kluth, Mark A, Bernreuther, Christian, Thurm, Dana, Jorissen, Ellen, Petrowitz, Bettina, Bartsch, Udo, De Strooper, Bart, Saftig, Paul, Glatzel, Markus
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3224557/
https://ncbi.nlm.nih.gov/pubmed/21619641
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-6-36
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