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Reduced Expression of VEGF-A in Human Retinal Pigment Epithelial Cells and Human Muller Cells Following CRISPR-Cas9 Ribonucleoprotein-Mediated Gene Disruption
PURPOSE: To evaluate the effects of vascular endothelial growth factor-A (VEGF-A) gene editing in human retinal pigment epithelial (RPE) cells and human Muller cells, which are the main VEGF-A producing cells in the eye. METHODS: CRISPR-Cas9 ribonucleoprotein was used to target exon 1 in VEGF-A gene...
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| Udgivet i: | Transl Vis Sci Technol |
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| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Association for Research in Vision and Ophthalmology
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7422915/ https://ncbi.nlm.nih.gov/pubmed/32855870 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/tvst.9.8.23 |
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