Significance of BRCA2 and RB1 co-loss in aggressive prostate cancer progression

PURPOSE: Previous sequencing studies revealed that alterations of genes associated with DNA damage response (DDR) are enriched in men with metastatic castration-resistant prostate cancer (mCRPC). BRCA2, a DDR and cancer susceptibility gene, is frequently deleted (homozygous and heterozygous) in men...

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Udgivet i:Clin Cancer Res
Main Authors: Chakraborty, Goutam, Armenia, Joshua, Mazzu, Ying Z., Nandakumar, Subhiksha, Stopsack, Konrad H., Atiq, Mohammad, Komura, Kazumasa, Jehane, Lina E., Hirani, Rahim, Chadalavada, Kalyani, Yoshikawa, Yuki, Khan, Nabeela, Chen, Yu, Abida, Wassim, Mucci, Lorelei A., Lee, Gwo-Shu Mary, Nanjangud, Gouri, Kantoff, Philip W.
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7416644/
https://ncbi.nlm.nih.gov/pubmed/31796516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-1570
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