Significance of BRCA2 and RB1 co-loss in aggressive prostate cancer progression

PURPOSE: Previous sequencing studies revealed that alterations of genes associated with DNA damage response (DDR) are enriched in men with metastatic castration-resistant prostate cancer (mCRPC). BRCA2, a DDR and cancer susceptibility gene, is frequently deleted (homozygous and heterozygous) in men...

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Pubblicato in:Clin Cancer Res
Autori principali: Chakraborty, Goutam, Armenia, Joshua, Mazzu, Ying Z., Nandakumar, Subhiksha, Stopsack, Konrad H., Atiq, Mohammad, Komura, Kazumasa, Jehane, Lina E., Hirani, Rahim, Chadalavada, Kalyani, Yoshikawa, Yuki, Khan, Nabeela, Chen, Yu, Abida, Wassim, Mucci, Lorelei A., Lee, Gwo-Shu Mary, Nanjangud, Gouri, Kantoff, Philip W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7416644/
https://ncbi.nlm.nih.gov/pubmed/31796516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-19-1570
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