Attenuation of SRC kinase activity augments PARP inhibitor–mediated synthetic lethality in BRCA2-altered prostate tumors

PURPOSE: Alterations in DNA damage repair (DDR) pathway genes occur in 20–25% of men with metastatic castration-resistant prostate cancer (mCRPC). Although poly (adenosine diphosphate [ADP]-ribose) polymerase inhibitors (PARPi) have been shown to benefit men with mCRPC harboring DDR defects due to m...

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Publicado no:Clin Cancer Res
Main Authors: Chakraborty, Goutam, Patail, Nabeela Khan, Hirani, Rahim, Nandakumar, Subhiksha, Mazzu, Ying Z., Yoshikawa, Yuki, Atiq, Mohammad, Jehane, Lina E., Stopsack, Konrad H., Lee, Gwo-Shu Mary, Abida, Wassim, Morris, Michael J., Mucci, Lorelei A., Danila, Daniel, Kantoff, Philip W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7956224/
https://ncbi.nlm.nih.gov/pubmed/33334906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-20-2483
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