Combinatorial inhibition of focal adhesion kinase and BCL-2 enhances anti-leukemia activity of venetoclax in acute myeloid leukemia

Focal adhesion kinase (FAK) promotes cancer cell growth and metastasis. We previously reported that FAK inhibition by the selective inhibitor VS-4718 exerted anti-leukemia activities in AML. The mechanisms involved, and whether VS-4718 potentiates efficacy of other therapeutic agents, have not been...

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Publicat a:Mol Cancer Ther
Autors principals: Wang, Xiangmeng, Mak, Po Yee, Mu, Hong, Tao, Wenjing, Rao, Arvind, Visweswaran, Ravikumar, Ruvolo, Vivian, Pachter, Jonathan A., Weaver, David T., Andreeff, Michael, Xu, Bing, Carter, Bing Z.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7416436/
https://ncbi.nlm.nih.gov/pubmed/32404407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-19-0841
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