Mammalian SWI/SNF complex genomic alterations and immune checkpoint blockade in solid tumors

Prior data have variably implicated the inactivation of the mammalian SWItch/Sucrose Non-Fermentable (mSWI/SNF) complex with increased tumor sensitivity to immune checkpoint inhibitors (ICIs). Herein, we examined the association between mSWI/SNF variants and clinical outcomes to ICIs. We correlated...

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Publicado no:Cancer Immunol Res
Main Authors: Alaiwi, Sarah Abou, Nassar, Amin H., Xie, Wanling, Bakouny, Ziad, Berchuck, Jacob E., Braun, David A., Baca, Sylvan C., Nuzzo, Pier Vitale, Flippot, Ronan, Mouhieddine, Tarek H., Spurr, Liam F., Li, Yvonne Y., Li, Taiwen, Flaifel, Abdallah, Steinharter, John A., Margolis, Claire A., Vokes, Natalie I., Du, Heng, Shukla, Sachet A., Cherniack, Andrew D., Sonpavde, Guru, Haddad, Robert I., Awad, Mark M., Giannakis, Marios, Hodi, F. Stephen, Liu, X. Shirley, Signoretti, Sabina, Kadoch, Cigall, Freedman, Matthew L., Kwiatkowski, David J., Van Allen, Eliezer, Choueiri, Toni K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7415546/
https://ncbi.nlm.nih.gov/pubmed/32321774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-19-0866
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