Structurally distinct cyclosporin and sanglifehrin analogs CRV431 and NV556 suppress established HCV infection in humanized-liver mice

We previously reported that the non-immunosuppressive cyclophilin inhibitors (CypIs)—cyclosporin A analog CRV431 and sanglifehrin analog NV556—efficiently inhibit HCV replication in vitro. In this study, we asked whether they can also reduce HCV replication in vivo. We found that a single oral admin...

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Библиографические подробности
Опубликовано в: :PLoS One
Главные авторы: Bobardt, Michael, Hansson, Magnus Joakim, Mayo, Patrick, Ure, Daren, Foster, Robert, Gallay, Philippe
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2020
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7413547/
https://ncbi.nlm.nih.gov/pubmed/32764799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0237236
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