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A Pan-Cyclophilin Inhibitor, CRV431, Decreases Fibrosis and Tumor Development in Chronic Liver Disease Models

Previous studies show that cyclophilins contribute to many pathologic processes, and cyclophilin inhibitors demonstrate therapeutic activities in many experimental models. However, no drug with cyclophilin inhibition as the primary mode of action has advanced completely through clinical development...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Kuo, Joseph, Bobardt, Michael, Chatterji, Udayan, Mayo, Patrick R., Trepanier, Daniel J., Foster, Robert T., Gallay, Philippe, Ure, Daren R.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6815936/
https://ncbi.nlm.nih.gov/pubmed/31406003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.119.261099
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