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A Pan-Cyclophilin Inhibitor, CRV431, Decreases Fibrosis and Tumor Development in Chronic Liver Disease Models

Previous studies show that cyclophilins contribute to many pathologic processes, and cyclophilin inhibitors demonstrate therapeutic activities in many experimental models. However, no drug with cyclophilin inhibition as the primary mode of action has advanced completely through clinical development...

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Bibliografski detalji
Izdano u:J Pharmacol Exp Ther
Glavni autori: Kuo, Joseph, Bobardt, Michael, Chatterji, Udayan, Mayo, Patrick R., Trepanier, Daniel J., Foster, Robert T., Gallay, Philippe, Ure, Daren R.
Format: Artigo
Jezik:Inglês
Izdano: The American Society for Pharmacology and Experimental Therapeutics 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6815936/
https://ncbi.nlm.nih.gov/pubmed/31406003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.119.261099
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