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In Vitro Phase I Metabolism of CRV431, a Novel Oral Drug Candidate for Chronic Hepatitis B

The cytochrome P450-mediated Phase I in vitro metabolism of CRV431 was studied using selective chemical inhibition and recombinant human enzymes. Additionally, the metabolic profile of CRV431 in human, rat, and monkey liver microsomes was investigated. Liver microsomes were incubated for 0–80 min wi...

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Vydáno v:Pharmaceutics
Hlavní autoři: Trepanier, Daniel J., Ure, Daren R., Foster, Robert T.
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5750657/
https://ncbi.nlm.nih.gov/pubmed/29120380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics9040051
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