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Competition NMR for Detection of Hit/Lead Inhibitors of Protein–Protein Interactions
Screening for small-molecule fragments that can lead to potent inhibitors of protein–protein interactions (PPIs) is often a laborious step as the fragments cannot dissociate the targeted PPI due to their low μM–mM affinities. Here, we describe an NMR competition assay called w-AIDA-NMR (weak-antagon...
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| Yayımlandı: | Molecules |
|---|---|
| Asıl Yazarlar: | , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
MDPI
2020
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7412237/ https://ncbi.nlm.nih.gov/pubmed/32630327 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules25133017 |
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