Nanoproteomics enables proteoform-resolved analysis of low-abundance proteins in human serum

Top-down mass spectrometry (MS)-based proteomics provides a comprehensive analysis of proteoforms to achieve a proteome-wide understanding of protein functions. However, the MS detection of low-abundance proteins from blood remains an unsolved challenge due to the extraordinary dynamic range of the...

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Udgivet i:Nat Commun
Main Authors: Tiambeng, Timothy N., Roberts, David S., Brown, Kyle A., Zhu, Yanlong, Chen, Bifan, Wu, Zhijie, Mitchell, Stanford D., Guardado-Alvarez, Tania M., Jin, Song, Ge, Ying
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7411019/
https://ncbi.nlm.nih.gov/pubmed/32764543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17643-1
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