Synthetic DNA Delivery of an Engineered Arginase Enzyme Can Modulate Specific Immunity In Vivo

Arginase is a complex and unique enzyme that plays diverse roles in health and disease. By metabolizing arginine, it can shape the outcome of innate and adaptive immune responses. The immunomodulatory capabilities of arginase could potentially be applied for local immunosuppression or induction of i...

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Veröffentlicht in:Mol Ther Methods Clin Dev
Hauptverfasser: Khoshnejad, Makan, Perales-Puchalt, Alfredo, Dia, Yaya, Xiao, Peng, Patel, Ami, Xu, Ziyang, Zhu, Xizhou, Yun, Kun, Baboo, Ishana, Qureshi, Rehman, Humeau, Laurent, Muthumani, Kar, Weiner, David B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Gene & Cell Therapy 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7406982/
https://ncbi.nlm.nih.gov/pubmed/32802913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2020.05.025
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