Simplifying checkpoint inhibitor delivery through in vivo generation of synthetic DNA-encoded monoclonal antibodies (DMAbs)

Checkpoint inhibitors (CPI) have revolutionized the treatment of many solid tumors. However, difficulties in production, stability, the requirement of frequent high doses for antibody administration and long intravenous administration are recurring issues. Synthetically designed DNA-encoded monoclon...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Perales-Puchalt, Alfredo, Duperret, Elizabeth K., Muthumani, Kar, Weiner, David B.
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2019
Subjects:
Research Perspective
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6343757/
https://ncbi.nlm.nih.gov/pubmed/30713599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26535
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