Synthetic DNA delivery by electroporation promotes robust in vivo sulfation of broadly neutralizing anti-HIV immunoadhesin eCD4-Ig

BACKGROUND: Despite vigorous and ongoing efforts, active immunizations have yet to induce broadly neutralizing antibodies (bNAbs) against HIV-1. An alternative approach is to achieve prophylaxis with long-term expression of potent biologic HIV-1 inhibitors with Adeno-associated Virus (AAV), which co...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Xu, Ziyang, Wise, Megan C., Choi, Hyeree, Perales-Puchalt, Alfredo, Patel, Ami, Tello-Ruiz, Edgar, Chu, Jacqueline D., Muthumani, Kar, Weiner, David B.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2018
Assuntos:
Research paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6161476/
https://ncbi.nlm.nih.gov/pubmed/30174283
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.08.027
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