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In vivo delivery of synthetic DNA–encoded antibodies induces broad HIV-1–neutralizing activity

Interventions to prevent HIV-1 infection and alternative tools in HIV cure therapy remain pressing goals. Recently, numerous broadly neutralizing HIV-1 monoclonal antibodies (bNAbs) have been developed that possess the characteristics necessary for potential prophylactic or therapeutic approaches. H...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Wise, Megan C., Xu, Ziyang, Tello-Ruiz, Edgar, Beck, Charles, Trautz, Aspen, Patel, Ami, Elliott, Sarah T.C., Chokkalingam, Neethu, Kim, Sophie, Kerkau, Melissa G., Muthumani, Kar, Jiang, Jingjing, Fisher, Paul D., Ramos, Stephany J., Smith, Trevor R.F., Mendoza, Janess, Broderick, Kate E., Montefiori, David C., Ferrari, Guido, Kulp, Daniel W., Humeau, Laurent M., Weiner, David B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6994112/
https://ncbi.nlm.nih.gov/pubmed/31697648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI132779
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