Synthetic DNA-encoded monoclonal antibody delivery of anti-CTLA-4 antibodies induces tumor shrinkage in vivo

Antibody-based immune therapies targeting the T cell checkpoint molecules CTLA-4 and PD-1 have impacted cancer therapy. However, this immune therapy requires complex manufacturing and frequent dosing, limiting the global use of this treatment. Here we focused on the development of a DNA-encoded mono...

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Publicado no:Cancer Res
Main Authors: Duperret, Elizabeth K., Trautz, Aspen, Stoltz, Regina, Patel, Ami, Wise, Megan C., Perales-Puchalt, Alfredo, Smith, Trevor, Broderick, Kate E., Masteller, Emma, Kim, J.Joseph, Humeau, Laurent, Muthumani, Kar, Weiner, David B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6239932/
https://ncbi.nlm.nih.gov/pubmed/30287678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-18-1429
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