Development of Novel DNA-Encoded PCSK9 Monoclonal Antibodies as Lipid-Lowering Therapeutics

Elevated low-density lipoprotein cholesterol (LDL-C) is one of the major contributors to cardiovascular heart disease (CHD), the leading cause of death worldwide. Due to severe side effects of statins, alternative treatment strategies are required for statin-intolerant patients. Monoclonal antibodie...

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Veröffentlicht in:Mol Ther
Hauptverfasser: Khoshnejad, Makan, Patel, Ami, Wojtak, Krzysztof, Kudchodkar, Sagar B., Humeau, Laurent, Lyssenko, Nicholas N., Rader, Daniel J., Muthumani, Kar, Weiner, David B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Gene & Cell Therapy 2019
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6319316/
https://ncbi.nlm.nih.gov/pubmed/30449662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2018.10.016
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