In Vivo Delivery of a DNA-Encoded Monoclonal Antibody Protects Non-human Primates against Zika Virus

Zika virus (ZIKV) infection is endemic to several world regions, and many others are at high risk for seasonal outbreaks. Synthetic DNA-encoded monoclonal antibody (DMAb) is an approach that enables in vivo delivery of highly potent mAbs to control infections. We engineered DMAb-ZK190, encoding the...

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Publicado en:Mol Ther
Main Authors: Esquivel, Rianne N., Patel, Ami, Kudchodkar, Sagar B., Park, Daniel H., Stettler, Karin, Beltramello, Martina, Allen, Jeffrey W., Mendoza, Janess, Ramos, Stephanie, Choi, Hyeree, Borole, Piyush, Asija, Kanika, Bah, Mamadou, Shaheen, Shareef, Chen, Jing, Yan, Jian, Durham, Amy C., Smith, Trevor R.F., Broderick, Kate, Guibinga, Ghiabe, Muthumani, Kar, Corti, Davide, Humeau, Laurent, Weiner, David B.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Gene & Cell Therapy 2019
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6520333/
https://ncbi.nlm.nih.gov/pubmed/30962164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2019.03.005
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