Synthetic DNA Delivery of an Engineered Arginase Enzyme Can Modulate Specific Immunity In Vivo

Arginase is a complex and unique enzyme that plays diverse roles in health and disease. By metabolizing arginine, it can shape the outcome of innate and adaptive immune responses. The immunomodulatory capabilities of arginase could potentially be applied for local immunosuppression or induction of i...

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Pubblicato in:Mol Ther Methods Clin Dev
Autori principali: Khoshnejad, Makan, Perales-Puchalt, Alfredo, Dia, Yaya, Xiao, Peng, Patel, Ami, Xu, Ziyang, Zhu, Xizhou, Yun, Kun, Baboo, Ishana, Qureshi, Rehman, Humeau, Laurent, Muthumani, Kar, Weiner, David B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7406982/
https://ncbi.nlm.nih.gov/pubmed/32802913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2020.05.025
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