Deletion of Calcineurin in Schwann Cells Does Not Affect Developmental Myelination, But Reduces Autophagy and Delays Myelin Clearance after Peripheral Nerve Injury

In the PNS, myelination occurs postnatally when Schwann cells (SCs) contact axons. Axonal factors, such as Neuregulin-1 Type III, trigger promyelinating signals that upregulate myelin genes. Neuregulin-1 Type III has been proposed to activate calcineurin signaling in immature SCs to initiate differe...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Reed, Chelsey B., Frick, Luciana R., Weaver, Adam, Sidoli, Mariapaola, Schlant, Elizabeth, Feltri, M. Laura, Wrabetz, Lawrence
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7406276/
https://ncbi.nlm.nih.gov/pubmed/32641402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0951-20.2020
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