Ablation of Perk in Schwann Cells Improves Myelination in the S63del Charcot-Marie-Tooth 1B Mouse

In factory cells, the accumulation of misfolded protein provokes the unfolded protein response (UPR). For example, deletion of serine 63 (S63del) in myelin protein zero (P0) induces P0 accumulation in the endoplasmic reticulum (ER) of Schwann cells and a persistent UPR associated with Charcot-Marie-...

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Detalles Bibliográficos
Publicado en:J Neurosci
Main Authors: Sidoli, Mariapaola, Musner, Nicolò, Silvestri, Nicholas, Ungaro, Daniela, D'Antonio, Maurizio, Cavener, Douglas R., Feltri, M. Laura, Wrabetz, Lawrence
Formato: Artigo
Idioma:Inglês
Publicado: Society for Neuroscience 2016
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Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5148247/
https://ncbi.nlm.nih.gov/pubmed/27807175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1637-16.2016
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