Perk Ablation Ameliorates Myelination in S63del-Charcot–Marie–Tooth 1B Neuropathy

In peripheral nerves, P0 glycoprotein accounts for more than 20% of myelin protein content. P0 is synthesized by Schwann cells, processed in the endoplasmic reticulum (ER) and enters the secretory pathway. However, the mutant P0 with S63 deleted (P0S63del) accumulates in the ER lumen and induces a d...

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Bibliografiska uppgifter
I publikationen:ASN Neuro
Huvudupphovsmän: Musner, Nicolò, Sidoli, Mariapaola, Zambroni, Desireè, Del Carro, Ubaldo, Ungaro, Daniela, D’Antonio, Maurizio, Feltri, Maria L., Wrabetz, Lawrence
Materialtyp: Artigo
Språk:Inglês
Publicerad: SAGE Publications 2016
Ämnen:
Original Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4844932/
https://ncbi.nlm.nih.gov/pubmed/27095827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1759091416642351
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