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Inter-Regulation of K(v)4.3 and Voltage-Gated Sodium Channels Underlies Predisposition to Cardiac and Neuronal Channelopathies

Background: Genetic variants in voltage-gated sodium channels (Na(v)) encoded by SCNXA genes, responsible for I(Na), and K(v)4.3 channels encoded by KCND3, responsible for the transient outward current (I(to)), contribute to the manifestation of both Brugada syndrome (BrS) and spinocerebellar ataxia...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Int J Mol Sci
Prif Awduron: Clatot, Jérôme, Neyroud, Nathalie, Cox, Robert, Souil, Charlotte, Huang, Jing, Guicheney, Pascale, Antzelevitch, Charles
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7404392/
https://ncbi.nlm.nih.gov/pubmed/32709127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21145057
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