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SHLD2 promotes class switch recombination by preventing inactivating deletions within the Igh locus
The newly identified shieldin complex, composed of SHLD1, SHLD2, SHLD3, and REV7, lies downstream of 53BP1 and acts to inhibit DNA resection and promote NHEJ. Here, we show that Shld2 (−/−) mice have defective class switch recombination (CSR) and that loss of SHLD2 can suppress the embryonic lethali...
Shranjeno v:
| izdano v: | EMBO Rep |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
John Wiley and Sons Inc.
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7403657/ https://ncbi.nlm.nih.gov/pubmed/32558186 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201949823 |
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