The H2B deubiquitinase Usp22 promotes antibody class switch recombination by facilitating non-homologous end joining

Class switch recombination (CSR) has a fundamental function during humoral immune response and involves the induction and subsequent repair of DNA breaks in the immunoglobulin (Ig) switch regions. Here we show the role of Usp22, the SAGA complex deubiquitinase that removes ubiquitin from H2B-K120, i...

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Publicado en:Nat Commun
Main Authors: Li, Conglei, Irrazabal, Thergiory, So, Clare C., Berru, Maribel, Du, Likun, Lam, Evelyn, Ling, Alexanda K., Gommerman, Jennifer L., Pan-Hammarström, Qiang, Martin, Alberto
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5843634/
https://ncbi.nlm.nih.gov/pubmed/29520062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03455-x
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