The deubiquitinase USP22 regulates PD-L1 degradation in human cancer cells

BACKGROUND: Many cancers evade immune surveillance by overexpressing PD-L1. PD-L1 interacted with its receptor PD-1, resulting in reduction of T cell proliferation and activation and thereafter cancer cell death mediated by T-lymphocyte. Understanding the mechanisms that regulate PD-L1 was of vital...

Full description

Saved in:
Bibliographic Details
Published in:Cell Commun Signal
Main Authors: Wang, Yu, Sun, Qingguo, Mu, Ning, Sun, Xiaoyang, Wang, Yingying, Fan, Songqing, Su, Ling, Liu, Xiangguo
Format: Artigo
Language:Inglês
Published: BioMed Central 2020
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7362500/
https://ncbi.nlm.nih.gov/pubmed/32665011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-020-00612-y
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items