USP14 is a deubiquitinase for Ku70 and critical determinant of non-homologous end joining repair in autophagy and PTEN-deficient cells

Ionizing radiation (IR)-induced DNA double-strand breaks (DSBs) are predominantly repaired by non-homologous end joining (NHEJ). IR-induced DNA damage activates autophagy, an intracellular degradation process that delivers cytoplasmic components to the lysosome. We identified the deubiquitinase USP1...

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Bibliografische gegevens
Gepubliceerd in:Nucleic Acids Res
Hoofdauteurs: Sharma, Arishya, Alswillah, Turkeya, Kapoor, Isha, Debjani, Pal, Willard, Belinda, Summers, Matthew K, Gong, Zihua, Almasan, Alexandru
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2020
Onderwerpen:
Genome Integrity, Repair and Replication
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7145659/
https://ncbi.nlm.nih.gov/pubmed/31740976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz1103
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