Mediator facilitates transcriptional activation and dynamic long-range contacts at the IgH locus during class switch recombination

Immunoglobulin (Ig) class switch recombination (CSR) is initiated by the transcription-coupled recruitment of activation-induced cytidine deaminase (AID) to Ig switch regions (S regions). During CSR, the IgH locus undergoes dynamic three-dimensional structural changes in which promoters, enhancers,...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Thomas-Claudepierre, Anne-Sophie, Robert, Isabelle, Rocha, Pedro P., Raviram, Ramya, Schiavo, Ebe, Heyer, Vincent, Bonneau, Richard, Luo, Vincent M., Reddy, Janardan K., Borggrefe, Tilman, Skok, Jane A., Reina-San-Martin, Bernardo
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2016
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Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4813673/
https://ncbi.nlm.nih.gov/pubmed/26903242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20141967
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