A Damage-Independent Role for 53BP1 that Impacts Break Order and Igh Architecture during Class Switch Recombination

During class switch recombination (CSR), B cells replace the Igh Cμ or δ exons with another down-stream constant region exon (C(H)), altering the anti-body isotype. CSR occurs through the introduction of AID-mediated double-strand breaks (DSBs) in switch regions and subsequent ligation of broken end...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Rocha, Pedro P., Raviram, Ramya, Fu, Yi, Kim, JungHyun, Luo, Vincent M., Aljoufi, Arafat, Swanzey, Emily, Pasquarella, Alessandra, Balestrini, Alessia, Miraldi, Emily R., Bonneau, Richard, Petrini, John, Schotta, Gunnar, Skok, Jane A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4927351/
https://ncbi.nlm.nih.gov/pubmed/27320916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.05.073
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