A Damage-Independent Role for 53BP1 that Impacts Break Order and Igh Architecture during Class Switch Recombination

During class switch recombination (CSR), B cells replace the Igh Cμ or δ exons with another down-stream constant region exon (C(H)), altering the anti-body isotype. CSR occurs through the introduction of AID-mediated double-strand breaks (DSBs) in switch regions and subsequent ligation of broken end...

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Gepubliceerd in:Cell Rep
Hoofdauteurs: Rocha, Pedro P., Raviram, Ramya, Fu, Yi, Kim, JungHyun, Luo, Vincent M., Aljoufi, Arafat, Swanzey, Emily, Pasquarella, Alessandra, Balestrini, Alessia, Miraldi, Emily R., Bonneau, Richard, Petrini, John, Schotta, Gunnar, Skok, Jane A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4927351/
https://ncbi.nlm.nih.gov/pubmed/27320916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2016.05.073
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