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SARM1 acts downstream of neuroinflammatory and necroptotic signaling to induce axon degeneration

Neuroinflammation and necroptosis are major contributors to neurodegenerative disease, and axon dysfunction and degeneration is often an initiating event. SARM1 is the central executioner of pathological axon degeneration. Here, we demonstrate functional and mechanistic links among these three pro-d...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Cell Biol
Egile Nagusiak: Ko, Kwang Woo, Milbrandt, Jeffrey, DiAntonio, Aaron
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Rockefeller University Press 2020
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7401797/
https://ncbi.nlm.nih.gov/pubmed/32609299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201912047
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