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Dorsoventral polarity directs cell responses to migration track geometries

How migrating cells differentially adapt and respond to extracellular track geometries remains unknown. Using intravital imaging, we demonstrate that invading cells exhibit dorsoventral (top-to-bottom) polarity in vivo. To investigate the impact of dorsoventral polarity on cell locomotion through di...

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Veröffentlicht in:Sci Adv
Hauptverfasser: Wisniewski, Emily O., Mistriotis, Panagiotis, Bera, Kaustav, Law, Robert A., Zhang, Jitao, Nikolic, Milos, Weiger, Michael, Parlani, Maria, Tuntithavornwat, Soontorn, Afthinos, Alexandros, Zhao, Runchen, Wirtz, Denis, Kalab, Petr, Scarcelli, Giuliano, Friedl, Peter, Konstantopoulos, Konstantinos
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Association for the Advancement of Science 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7399493/
https://ncbi.nlm.nih.gov/pubmed/32789173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aba6505
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