The fluid shear stress sensor TRPM7 regulates tumor cell intravasation

Tumor cell intravasation preferentially occurs in regions of low fluid shear because high shear is detrimental to tumor cells. Here, we describe a molecular mechanism by which cells avoid high shear during intravasation. The transition from migration to intravasation was modeled using a microfluidic...

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Bibliografski detalji
Izdano u:Sci Adv
Glavni autori: Yankaskas, Christopher L., Bera, Kaustav, Stoletov, Konstantin, Serra, Selma A., Carrillo-Garcia, Julia, Tuntithavornwat, Soontorn, Mistriotis, Panagiotis, Lewis, John D., Valverde, Miguel A., Konstantopoulos, Konstantinos
Format: Artigo
Jezik:Inglês
Izdano: American Association for the Advancement of Science 2021
Teme:
Research Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC8270498/
https://ncbi.nlm.nih.gov/pubmed/34244134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abh3457
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