The fluid shear stress sensor TRPM7 regulates tumor cell intravasation

Tumor cell intravasation preferentially occurs in regions of low fluid shear because high shear is detrimental to tumor cells. Here, we describe a molecular mechanism by which cells avoid high shear during intravasation. The transition from migration to intravasation was modeled using a microfluidic...

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Detalhes bibliográficos
Publicado no:Sci Adv
Main Authors: Yankaskas, Christopher L., Bera, Kaustav, Stoletov, Konstantin, Serra, Selma A., Carrillo-Garcia, Julia, Tuntithavornwat, Soontorn, Mistriotis, Panagiotis, Lewis, John D., Valverde, Miguel A., Konstantopoulos, Konstantinos
Formato: Artigo
Idioma:Inglês
Publicado em: American Association for the Advancement of Science 2021
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8270498/
https://ncbi.nlm.nih.gov/pubmed/34244134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abh3457
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