In vitrometabolic mapping of neobavaisoflavone in human cytochromes P450 and UDP-glucuronosyltransferase enzymes by ultra high-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry

Neobavaisoflavone (NBIF), a phenolic compound isolated from Psoralea corylifolia L., possesses several significant biological properties. However, the pharmacokinetic behaviors of NBIF have been characterized as rapid oral absorption, high clearance, and poor oral bioavailability. We found that NBIF...

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Published in:J Pharm Biomed Anal
Main Authors: Xu, Jinjin, Li, Mengsen, Yao, Zhihong, Zhang, Yezi, Li, Shishi, Hu, Liufang, Qin, Zifei, Gonzalez, Frank J., Yao, Xinsheng
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7396963/
https://ncbi.nlm.nih.gov/pubmed/29933228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2018.06.022
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