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Mechanism of the efflux transport of demethoxycurcumin-O-glucuronides in HeLa cells stably transfected with UDP-glucuronosyltransferase 1A1

Demethoxycurcumin (DMC) is a safe and natural food-coloring additive, as well as an agent with several therapeutic properties. However, extensive glucuronidation in vivo has resulted in its poor bioavailability. In this study, we aimed to investigate the formation of DMC-O-glucuronides by uridine 5&...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Zhang, Beibei, Yang, Jing, Qin, Zifei, Li, Shishi, Xu, Jinjin, Yao, Zhihong, Zhang, Xiaojian, Gonzalez, Frank J., Yao, Xinsheng
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6544300/
https://ncbi.nlm.nih.gov/pubmed/31150474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0217695
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