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Mechanism of the efflux transport of demethoxycurcumin-O-glucuronides in HeLa cells stably transfected with UDP-glucuronosyltransferase 1A1

Demethoxycurcumin (DMC) is a safe and natural food-coloring additive, as well as an agent with several therapeutic properties. However, extensive glucuronidation in vivo has resulted in its poor bioavailability. In this study, we aimed to investigate the formation of DMC-O-glucuronides by uridine 5&...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Zhang, Beibei, Yang, Jing, Qin, Zifei, Li, Shishi, Xu, Jinjin, Yao, Zhihong, Zhang, Xiaojian, Gonzalez, Frank J., Yao, Xinsheng
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6544300/
https://ncbi.nlm.nih.gov/pubmed/31150474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0217695
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