Mechanism of the efflux transport of demethoxycurcumin-O-glucuronides in HeLa cells stably transfected with UDP-glucuronosyltransferase 1A1

Demethoxycurcumin (DMC) is a safe and natural food-coloring additive, as well as an agent with several therapeutic properties. However, extensive glucuronidation in vivo has resulted in its poor bioavailability. In this study, we aimed to investigate the formation of DMC-O-glucuronides by uridine 5&...

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Publicado en:PLoS One
Autores principales: Zhang, Beibei, Yang, Jing, Qin, Zifei, Li, Shishi, Xu, Jinjin, Yao, Zhihong, Zhang, Xiaojian, Gonzalez, Frank J., Yao, Xinsheng
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2019
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6544300/
https://ncbi.nlm.nih.gov/pubmed/31150474
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0217695
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