Structure-based development of a subtype-selective orexin 1 receptor antagonist

Orexins are neuropeptides that activate the rhodopsin-like G protein-coupled receptors OX1R and OX2R. The orexin system plays an important role in the regulation of the sleep-wake cycle and the regulation of feeding and emotions. The nonselective orexin receptor antagonist suvorexant has been the fi...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Hellmann, Jan, Drabek, Matthäus, Yin, Jie, Gunera, Jakub, Pröll, Theresa, Kraus, Frank, Langmead, Christopher J., Hübner, Harald, Weikert, Dorothee, Kolb, Peter, Rosenbaum, Daniel M., Gmeiner, Peter
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2020
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7395530/
https://ncbi.nlm.nih.gov/pubmed/32669442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2002704117
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