The Dual Orexin Receptor Antagonist Almorexant Induces Sleep and Decreases Orexin-Induced Locomotion by Blocking Orexin 2 Receptors

STUDY OBJECTIVES: Orexin peptides activate orexin 1 and orexin 2 receptors (OX(1)R and OX(2)R), regulate locomotion and sleep-wake. The dual OX(1)R/OX(2)R antagonist almorexant reduces activity and promotes sleep in multiple species, including man. The relative contributions of the two receptors in...

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Main Authors: Mang, Géraldine M., Dürst, Thomas, Bürki, Hugo, Imobersteg, Stefan, Abramowski, Dorothee, Schuepbach, Edi, Hoyer, Daniel, Fendt, Markus, Gee, Christine E.
Format: Artigo
Sprog:Inglês
Udgivet: Associated Professional Sleep Societies, LLC 2012
Fag:
Dual Orexin Receptor Antagonist Almorexant Induces Sleep
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3490355/
https://ncbi.nlm.nih.gov/pubmed/23204605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5665/sleep.2232
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