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Restoring Herpesvirus Entry Mediator (HVEM) Immune Function in HVEM(−/−) Mice Rescues Herpes Simplex Virus 1 Latency and Reactivation Independently of Binding to Glycoprotein D

The immune modulatory protein herpes virus entry mediator (HVEM) is one of several cellular receptors used by herpes simplex virus 1 (HSV-1) for cell entry. HVEM binds to HSV-1 glycoprotein D (gD) but is not necessary for HSV-1 replication in vitro or in vivo. Previously, we showed that although HSV...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Tormanen, Kati, Wang, Shaohui, Jaggi, Ujjaldeep, Ghiasi, Homayon
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7394883/
https://ncbi.nlm.nih.gov/pubmed/32522859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00700-20
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