Expression of Murine CD80 by Herpes Simplex Virus 1 in Place of Latency-Associated Transcript (LAT) Can Compensate for Latency Reactivation and Anti-apoptotic Functions of LAT

High rates of wild-type (WT) herpes simplex virus 1 (HSV-1) latency reactivation depend on the anti-apoptotic activities of latency-associated transcript (LAT). Replacing LAT with the baculovirus inhibitor of apoptosis protein (cpIAP) or cellular FLIP (FLICE-like inhibitory protein) gene restored th...

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Bibliographic Details
Published in:J Virol
Main Authors: Jaggi, Ujjaldeep, Matundan, Harry H., Tormanen, Kati, Wang, Shaohui, Yu, Jack, Mott, Kevin R., Ghiasi, Homayon
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2020
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7158736/
https://ncbi.nlm.nih.gov/pubmed/31852788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01798-19
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