Potent, selective, water soluble, brain-permeable EP2 receptor antagonist for use in central nervous system disease models

Activation of prostanoid EP2 receptor exacerbates neuroinflammatory and neurodegenerative pathology in central nervous system diseases such as epilepsy, Alzheimer’s disease and cerebral aneurysms. A selective and brain-permeable EP2 antagonist will be useful to attenuate the inflammatory consequence...

Full description

Saved in:
Bibliographic Details
Published in:J Med Chem
Main Authors: Amaradhi, Radhika, Banik, Avijit, Mohammed, Shabber, Patro, Vidyavathi, Rojas, Asheebo, Wang, Wenyi, Motati, Damoder Reddy, Dingledine, Ray, Ganesh, Thota
Format: Artigo
Language:Inglês
Published: 2020
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7394479/
https://ncbi.nlm.nih.gov/pubmed/31904232
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b01218
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items