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Peripherally restricted, highly potent, selective, aqueous-soluble EP2 antagonist with anti-inflammatory properties
The prostaglandin E(2) receptor, EP2, plays an important role in physiology and in a variety of pathological conditions. Studies indicate that EP2 is pro-inflammatory in chronic peripheral and central nervous system disease and cancer models. Thus, targeting the EP2 receptor with small molecules cou...
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| Publicado en: | Mol Pharm |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6633905/ https://ncbi.nlm.nih.gov/pubmed/30398879 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.8b00764 |
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