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Peripherally restricted, highly potent, selective, aqueous-soluble EP2 antagonist with anti-inflammatory properties

The prostaglandin E(2) receptor, EP2, plays an important role in physiology and in a variety of pathological conditions. Studies indicate that EP2 is pro-inflammatory in chronic peripheral and central nervous system disease and cancer models. Thus, targeting the EP2 receptor with small molecules cou...

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Detalhes bibliográficos
Publicado no:Mol Pharm
Main Authors: Ganesh, Thota, Banik, Avijit, Dingledine, Ray, Wang, Wenyi, Amaradhi, Radhika
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6633905/
https://ncbi.nlm.nih.gov/pubmed/30398879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.8b00764
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