Purine metabolism regulates DNA repair and therapy resistance in glioblastoma

Intratumoral genomic heterogeneity in glioblastoma (GBM) is a barrier to overcoming therapy resistance. Treatments that are effective independent of genotype are urgently needed. By correlating intracellular metabolite levels with radiation resistance across dozens of genomically-distinct models of...

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Vydáno v:Nat Commun
Hlavní autoři: Zhou, Weihua, Yao, Yangyang, Scott, Andrew J., Wilder-Romans, Kari, Dresser, Joseph J., Werner, Christian K., Sun, Hanshi, Pratt, Drew, Sajjakulnukit, Peter, Zhao, Shuang G., Davis, Mary, Nelson, Barbara S., Halbrook, Christopher J., Zhang, Li, Gatto, Francesco, Umemura, Yoshie, Walker, Angela K., Kachman, Maureen, Sarkaria, Jann N., Xiong, Jianping, Morgan, Meredith A., Rehemtualla, Alnawaz, Castro, Maria G., Lowenstein, Pedro, Chandrasekaran, Sriram, Lawrence, Theodore S., Lyssiotis, Costas A., Wahl, Daniel R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7393131/
https://ncbi.nlm.nih.gov/pubmed/32732914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-17512-x
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