Glioblastoma Therapy Can be Augmented by Targeting IDH1-mediated NADPH Biosynthesis

NADPH is a critical reductant needed in cancer cells to fuel the biosynthesis of deoxynucleotides and antioxidants and to sustain stress-survival responses after radiation-induced DNA damage. Thus, one rational strategy to attack cancer cells is to target their heavy reliance on NADPH. Here we repor...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Wahl, Daniel R., Dresser, Joseph, Wilder-Romans, Kari, Parsels, Joshua D., Zhao, Shuang G., Davis, Mary, Zhao, Lili, Kachman, Maureen, Wernisch, Stefanie, Burant, Charles F., Morgan, Meredith A., Feng, Felix Y., Speers, Corey, Lyssiotis, Costas A., Lawrence, Theodore S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5726266/
https://ncbi.nlm.nih.gov/pubmed/27923831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-2008
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados