EXTH-15. TARGETING ANDROGEN SIGNALING IN GLIOBLASTOMA (GBM) USING SEVITERONEL (SEVI), A CYP17 LYASE AND ANDROGEN RECEPTOR (AR) INHIBITOR, ALONE AND IN COMBINATION WITH RADIATION (RT)

The AR is a therapeutic target and a driver of growth and treatment resistance in prostate and breast cancer. Male sex is associated with increased GBM incidence and worsened prognosis but whether the AR is expressed or represents a therapeutic target in GBM is unknown. Using RNAseq and immunoblot,...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Neuro Oncol
Hauptverfasser: Sun, Hanshi, Werner, Christian, Dresser, Joseph, Wilder-Romans, Kari, Baskin-Bey, Edwina, Eisner, Joel, Lawrence, Theodore, Spratt, Daniel, Speers, Corey, Wahl, Daniel
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2018
Schlagworte:
Abstracts
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6217107/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.364
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge