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EXTH-15. TARGETING ANDROGEN SIGNALING IN GLIOBLASTOMA (GBM) USING SEVITERONEL (SEVI), A CYP17 LYASE AND ANDROGEN RECEPTOR (AR) INHIBITOR, ALONE AND IN COMBINATION WITH RADIATION (RT)
The AR is a therapeutic target and a driver of growth and treatment resistance in prostate and breast cancer. Male sex is associated with increased GBM incidence and worsened prognosis but whether the AR is expressed or represents a therapeutic target in GBM is unknown. Using RNAseq and immunoblot,...
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| Pubblicato in: | Neuro Oncol |
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| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6217107/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.364 |
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